Beilstein J. Org. Chem.2021,17, 293–318, doi:10.3762/bjoc.17.28
cell lines [44]. Here, the incorporation of CF3 and CF3O groups as NMR reporters into the tumour-targeting drug conjugates enabled the direct investigation of the mechanism of the pro-drug metabolic cleavage and the pharmacophore release by real-time 19F NMR analysis. 19F NMR was also employed as a
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Graphical Abstract
Figure 1:
Selected examples of 19F-labelled amino acid analogues used as probes in chemical biology.
Beilstein J. Org. Chem.2018,14, 1281–1286, doi:10.3762/bjoc.14.109
glycol spacer with a terminal azide results in a complete loss of activity. Docking studies of the novel cryptophycin analogues to β-tubulin provided a rationale for the observed cytotoxicities.
Keywords: cryptophycin; cytotoxic agents; novel payloads; tubulin inhibitors; tumourtargeting; Introduction